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| Job ID | Employer | Position | Description | Requirements | Location | Contact | Post Date |
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| SRI International |
Supervisor - Analytical Chemistry
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The Supervisor will provide analytical expertise and leadership supporting nonclinical safety studies conducted under Good Laboratory Practice regulations. The Supervisor will collaborate closely with other nonclinical development team members including formulation development, dose preparation, toxicology, pharmacokinetics, project management, and quality assurance.
The Supervisor will be asked to:
- Provide input in analytical method development, verification, validation, analysis of data, research techniques, and problem solving.
- Monitor the generation of analytical data, ensure appropriate and current test methods are used, and critically evaluate the validity of results.
- Write reports and respond to QA audits of raw data and reports.
- Supervise GLP analytical chemistry services and staff, write and review proposals and protocols, develop budgets for project tasks.
- Ensure adherence to SRI policies and quality programs.
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PhD and >5 years experience in chemistry or equivalent with coursework in Analytical Chemistry. Experience with GLP and/or cGMP regulations and supervisory experience desirable. Excellent oral and written communication and interpersonal skills and ability to work in fast paced team environment.
Post-offer, pre-laboratory physical examination will be required.
About SRI:
SRI International is a leader in the development of new products for the treatment and diagnosis of disease, primarily in the areas of cancer, infectious disease, neuroscience, and immunology. SRI's Biosciences Division works in several ways, conducting basic research like an academic institution, performing drug discovery and biologic development like a biotechnology company, and carrying out preclinical development and pharmaceutical services like a contract research organization - from "Idea to IND" (tm).
The Biosciences Division works with partners and clients on a broad range of preclinical discovery and development projects, utilizing its expertise in medicinal chemistry, custom organic synthesis, efficacy pharmacology and safety evaluation, pharmacokinetics and metabolism studies, analytical chemistry, formulation design, drug product manufacturing, project management and regulatory affairs. Many studies are conducted under FDA's GLP and GMP regulations. SRI currently has several drugs on the market, several more in clinical trials, half a dozen in preclinical development, and has assisted in the development of more than 130 other products that made it to clinical trials or reached the market.
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Menlo Park, CA
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Apply via our web page www.sri.com/jobs to job number 100559.
| 8/23/2010 9:30:06 AM |
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| University of California San Francisco |
Bioanalytical/HPLC-Mass Spectrometry Scientist
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The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco is seeking an outstanding and accomplished scientist with experience in Bioanalytical/HPLC-Mass Spectrometry (MS). S/he would immediately contribute to ongoing drug discovery programs in neurodegenerative diseases, including Creutzfeldt-Jakob disease, Alzheimer’s disease, Frontotemporal dementia, and Parkinson’s disease. The IND is building a highly focused and multidisciplinary team to develop effective pharmacologic treatments and predictive diagnostic markers for these diseases. Drug discovery research and development at the IND is headed by Dr. Michael Silber. The IND is comprised of scientists and faculty across multiple UC campuses. The successful candidate must be an outstanding M.S.- or Ph.D.- level Bioanalytical/HPLC-Mass Spectrometry scientist with substantial experience applying state-of-the-art liquid chromatography-mass spectrometry (LC-MS) (i.e., AB API-4000) to small molecule drug discovery and time of flight (TOF) MS (i.e., Orbitrap, TOF/TOF and Q/TOF etc.) to support analysis of proteins involved in neurodegenerative diseases. S/he will design pharmacokinetic (PK) studies, evaluate and select formulations, oversee PK and efficacy studies to ensure accurate dosing, harvesting and processing of biological samples. Most importantly, s/he will be 100% hands-on to independently operate LC-MS and TOF MS systems to analyze samples, generate and interpret results, and integrate these results to contribute to crucial decisions in each of our drug discovery and biology programs.
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Qualifications:
• M.S. or Ph.D. in Biological Sciences, Analytical Chemistry, Bioanalytical Chemistry, Biochemistry, or a related science.
• At least five to seven years of hands-on experience with AB API-4000 (required) and TOF MS (preferred) systems, independently operating, problem solving, and maintaining the MS systems, and quantifying and characterizing biological samples.
• Expertise in bioanalytical, PK, and pharmacology experimental design and critical analytical skills, including organic chemistry, chromatographic separations, mass spectrometry, and extraction techniques.
• Strong computer skills and proficiency with quantitative software and programming.
• Outstanding oral and written communication, problem solving, organizational, record keeping, and interpersonal skills.
Submit applications to:
Dr. Stanley Prusiner
University of California, San Francisco
Box 0518
San Francisco, CA 94143-0518
Email: ind@ind.ucsf.edu
The University of California, San Francisco is an equal opportunity employer.
*Refer to Bioanalytical/HPLC-Mass Spectrometry Scientist when applying for this position. Title will be commensurate with background, experience, and work history.
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San Francisco, CA
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ind@ind.ucsf.edu
| 8/18/2010 2:08:04 PM |
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Details>>
| University of California San Francisco, Institute for Neurodegenerative Diseases |
Bioanalytical Researcher – LCMS Focus
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The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco is seeking an outstanding and accomplished scientist with experience in Bioanalytical/HPLC-Mass Spectrometry. S/he would immediately contribute to ongoing drug discovery programs in neurodegenerative diseases, including Creutzfeldt-Jakob disease, Alzheimer’s disease, Frontotemporal dementia, and Parkinson’s disease. The IND is building a highly focused and multidisciplinary team to develop effective pharmacologic treatments and predictive diagnostic markers for these diseases. Drug discovery research and development at the IND is headed by Dr. Michael Silber. The IND is comprised of scientists and faculty across multiple UC campuses. The successful candidate must be an outstanding M.S. or Ph.D. level Bioanalytical/HPLC-Mass Spectrometry scientist with substantial experience applying state-of-the-art liquid chromatography-mass spectrometry (LC-MS) (i.e., AB API-4000) to small molecule drug discovery and time of flight (TOF) MS (i.e. Orbitrap, TOF/TOF and Q/TOF etc.) to support analysis of proteins involved in neurodegenerative diseases. S/he will design pharmacokinetic (PK) studies, evaluate and select formulations, oversee PK and efficacy studies to ensure accurate dosing, harvesting and processing of biological samples, and most importantly, be 100% hands-on to independently operate LC-MS and TOF MS systems to analyze samples, generate and interpret results, and integrate these results to contribute to crucial decisions in each of our drug discovery and biology programs.
The incumbent will be an outstanding BS/MS level bioanalytical researcher in the field of liquid chromatography-mass spectrometry (LC/MS-MS) to support drug discovery research in the small molecule area. S/he will be responsible for assay development and sample analysis in support of pharmacokinetic, drug metabolism, drug delivery and animal efficacy research in support of the IND’s drug discovery programs. S/he will play a key role in the evaluation and development of LC/MS-MS based assays and the analysis of samples, especially those generated from in-vivo studies in animals. Primary responsibility of the position is to provide bioanalytical support to the drug discovery program in CJD. The candidate will use broad scientific knowledge to contribute to sample preparation, LC/MS-MS method development, and data analysis. S/he will use his/her technical expertise to evaluate, select, and apply novel methodologies using state-of-the-art LC/MS-MS instrumentation, especially the Sciex API-4000. S/he will work independently to design and conduct bioanalytical experiments, and document, interpret, communicate, apply and publish results.
This is a remarkable opportunity for an accomplished bioanalytical researcher to work in a unique interdisciplinary environment in a “100% hands-on” position where collaborations are highly encouraged and many supporting core activities are readily available. All candidates with exceptional records of accomplishment in the LC/MS-MS area as applied to ADME/DMPK and drug discovery research will be considered. Relevant industrial (Pharma/Biotech/startup) experience preferable, but candidates with equivalent experience in an academic or nonprofit setting will be considered. The ideal candidate will have knowledge, experience, and a proven track record in the field of LC/MS-MS, demonstrated by accomplishments, including publications in peer-reviewed journals.
The candidate will perfrom transporter assays using radiolabeled substrates.The candidate may also be involved the preparation of plasmid DNA.
The candidate will perform routine cell culture.
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Qualifications:
•M.S. or Ph.D. in Biological Sciences, Analytical Chemistry, Bioanalytical Chemistry, Biochemistry, or a related science.
•At least five to seven years of hands-on experience with AB API-4000 (required) and a TOF MS (preferred) systems, independently operating, problem solving, and maintaining the MS systems, and quantifying and characterizing biological samples.
•Expertise in bioanalytical, PK, and pharmacology experimental design and critical analytical skills, including organic chemistry, chromatographic separations, mass spectrometry, and extraction techniques.
•Strong computer skills and proficiency with quantitative software and programming.
•Outstanding oral and written communication, problem solving, organizational, record keeping, and interpersonal skills.
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San Francisco, CA
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E-mail: ind@ind.ucsf.edu
| 8/18/2010 1:02:20 PM |
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Details>>
| ChemoCentryx Inc. |
DMPK Consultant / Part-time contractor
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ChemoCentryx needs a PK/bioanalytical consultant / part-time contractor who will be performing one or both of the following functions. The work can be done either on-site or from your home office with VPN access to the ChemoCentryx data server.
1) Writing of DMPK study reports for regulatory submission: based on the processed data and raw data for common DMPK studies such as in vivo PK and in vitro ADME (CYP450 inhibition, induction, protein binding, metabolic stability, metabolite ID, permeability) and you will produce formal reports to support regulatory filing. Report templates or example reports from previous programs will be provided to you.
2) Data interrogation / Quality control of discovery DMPK studies: you will examine the analytical data and processed data for routine in vitro and in vivo studies to ensure data integrity before data release to the project team.
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1) Intimate knowledge about various in vitro and in vivo studies, including the commonly accepted industry protocols / practices, LC-MS/MS data processing and DMPK calculation using Excel or other programs.
2) Excellent written skills.
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Mountain View, CA (or from home office)
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smiao@chemocentryx.com
| 8/16/2010 3:40:48 PM |
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| Crown Bioscience Inc. |
Biotherapeutics Scientist
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Crown is seeking to recruit a talented scientist to be responsible for study design, execution, and data interpretation aimed at evaluation of disposition, PK/PD, and immunogenicity of biotherapeutics (primarily monoclonal antibodies, mAbs) in support of oncology programs.
The successful candidate will work closely with a multi-disciplinary team, which includes biologists, protein biochemists, in vivo pharmacologists, and DMPK scientists to advance internal programs and aid in optimization of the lead molecules.
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• Broad understanding and highly skilled in routine laboratory techniques including quantitative ELISA, FACS, tissue and cell lysis and fractionation, Western blot and cell culture.
• Additional experience in the commonly used approaches to study disposition and PK/PD of monoclonal antibodies or understanding of pharmacokinetics of biotherapeutics is a plus.
• Able to analyze and format data using MS Excel or other analytical software, and to translate data into standard PK/PD and ADME report
• Proven analytical problem solving skills and ability to generate high quality data against challenging time lines.
• Effectively communicate across sites and disciplines.
• Familiar with collaborative and partnering research environment in a complex, multi-discipline organizational model.
• Able to relocate to Taicang, China (near Shanghai)
• PhD in Biology, Cell Biology, Biochemistry or relevant field; BS or MS with significant industry experience in relevant field
• Experience in biotherapeutic drug development with emphasis on PK/PD and ADME is a plus
• Good presentation skills demonstrated through internal and external presentations on own work and/or at conferences
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Taicang, China
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Michelle Xia: mxia@crownbio.com
| 8/13/2010 1:24:52 PM |
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| Bay Bioanalytical Laboratory |
Senior Mass Spectrometrist
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Mass Spectrometrist with knowledge of proteomics instrumentation, methods and software tools. MS with 3-5 years of experience, or Ph.D. with extensive protein characterization experience. Operation of QSTAR and in-depth knowledge of HPLC a plus.
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Experience: Mass Spectrometrist with knowledge of proteomics instrumentation, methods and software tools. MS with 3-5 years of experience, or Ph.D. with extensive protein characterization experience. Operation of QSTAR and in-depth knowledge of HPLC a plus.
Responsibilities:
• Operate and maintain QSTAR in ESI and APCI modes.
• Maintain up-to-date LC/MS/MS knowledge.
• Generate data in support of INDs, NDAs, and BLAs, mainly for the pharmaceutical and medical device industry.
• Job functions include
o operation, calibration and maintenance of triple quadrupole and QTOF hybrid mass spectrometers and associated HPLC systems. Familiarity with AB SCIEX instruments and software a plus
o protein characterization
o elucidation of peptide sequences
o characterization of unknown protein impurities
o determination of protein modifications including deamidation, alkylation, site of glycosylation,
o disulfide mapping
o exact mass determination of proteins and peptides
o some characterization of small molecules and related substances and impurities
o characterization of carbohydrates
o biomarker validation
o analysis of LC/MS data and writing of draft and final reports incorporating the data
o development and validation of LC/MS methods, including bioanalysis from plasma and tissues
o QC audit (review) raw data, results summaries, method validations, and final reports performed and written by other staff members
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Hercules, CA (SF East Bay)
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Bob Cunico Cell: (510) 367-7318 Office:(510) 724-8052 rlcunico@baybiolab.com
| 8/12/2010 12:10:45 PM |
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Details>>
| Relypsa |
Analytical Development RA to Scientist level (Multiple positions) Job Code SC001
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Relypsa has several positions open for Research Associate to Scientist level in the Analytical Group supporting late stage drug development. These positions can be temporary or permanent depending on the candidate.
RESPONSIBILITIES:
• Develop and validate analytical methods for release and stability testing
• Evaluate and improve existing tests and assays
• Identify impurities using advanced structural elucidation techniques
• Conduct routine analysis following SOPs
• Establish reference standard programs
• Write/review analytical test methods, protocols, reports and regulatory sections
• Compile, analyze and present analytical data for specification settings; document their justifications
• Coordinate analytical activities at CRO and CMO (method transfer, stability coordination, data review and approval)
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SKILLS/EXPERIENCE:
• Hands-on experience in wide range of state-of-the-art analytical techniques is a must (LC, LC/MS, IC, GC, GC/MS, SEC, IR, NMR, XRD, DSC, TA, Light Scattering)
• Excellent working knowledge of the ICH Guidelines regarding Quality and Stability Testing, GMPs and GLPs and other regulatory requirements from IND to NDA stage and beyond
• Experience with providing analytical support to process and formulation development (e.g. in-process monitoring, impurities assessments, excipient compatibility, bio-equivalency studies)
• Familiarity with approach to extractables using ultra sensitive chromatographic sampling and detection methods
• Ability to exercise independent judgment in developing methods and evaluation criteria for obtaining results
• Strong communication and interpersonal skills for a team-oriented environment, along with the ability to be flexible and collaborate on projects
• Experience with polymeric drugs is a plus
QUALIFICATIONS:
• BS, MS or PhD degree in Analytical Chemistry or related disciplines with 5+ years in analytical role supporting late stage drug development (recent Phase 3, NDA and drug product launch experience)
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Santa Clara, CA
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apply-sc001@relypsa.com
| 8/12/2010 6:34:19 AM |
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Details>>
| ChemoCentryx Inc. |
Senior Associate or Associate Scientist – DMPK / Bioanalytical
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this position will be involved in clinical PK sample bioanalysis and/or discovery ADME/DMPK support.
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the successful candidate needs to have M.Sc. or B.Sc. degree in chemistry, biochemistry, or a related field, and bioanalytical skills such as LCMS/MS method development and trouble-shooting. Experience in performing in vitro ADME assays is a plus. The candidate needs to have excellent oral communication and writing skills and work as a highly effective team member. Industrial experience of 1-5 years is required.
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Mountain View, CA
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smiao@chemocentryx.com
| 8/10/2010 1:43:20 PM |
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Details>>
| iPierian, Inc. |
Sr. Staff Scientist, Assay Development & Lead Discovery
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Serve as a team leader for designing, developing, and executing cell-based functional assays to support iPierian’s therapeutic programs. Responsibilities will include the development and implementation of high and medium throughput cell-based assays to support the discovery and development of new small molecule therapeutics. The successful candidate will work closely with colleagues in other department on projects ranging from early to late stage discovery. This individual will strongly advocate incorporating the latest assay and automation technologies to advance drug discovery process. This individual should be able to balance hands-on laboratory work with managerial responsibilities and management of external collaborations.
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• Ph.D. or equivalent degree
• At least 8+ years of industrial or academic experience in planning, development and execution of assays and screens for small molecule drug discovery
• Minimum 5 years of supervisory experience
• Experience in developing and optimizing novel assays in a variety of conventional and cutting edge formats and modalities, including formats using cell-based assays in complex cell cultures and/or primary cells is required
• Extensive experience in scaling up and qualifying assays for large scale screens is required
• Demonstrated research experience in neurobiology is preferred
• Excellent verbal and written skills are required
• Demonstrated ability to work in a fast paced multidisciplinary team
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So. San Francisco
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careers@ipierian.com
| 8/10/2010 11:02:08 AM |
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Details>>
| iPierian, Inc. |
Sr. Scientist, Assay Development & Lead Discovery
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Successful candidate will be responsible for design, development, and execution of high- and medium throughput cell-based assays in a variety of formats and screening modalities to support iPierian’s therapeutic programs. (S)he will work closely with colleagues on projects ranging from early to late stage discovery within a matrix organization. This individual will be capable of integrating the highest quality assay and automation technologies to advance the drug discovery process. The individual should be capable to take full responsibility of building an assay “from scratch” suitable for high volume screens, lead optimization and molecular target validation.
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• Ph.D. or equivalent degree
• 4-7 years of industrial or academic experience in planning, development and execution of assays and screens for small molecule drug discovery
• Experience in developing and optimizing novel assays in a variety of formats and modalities, including cell-based assays using complex cell cultures and/or primary cells is required. Versed in all types of biochemical assays focused on specific molecular targets.
• Extensive experience in qualifying assays for large scale screens is required
• Demonstrated research experience in neurobiology is preferred
• Ability to conduct a project that requires outsourcing of assay development and HTS activities
• Excellent verbal and written skills are required
• Demonstrated ability to work in a fast paced multidisciplinary team
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So. San Francisco
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careers@ipierian.com
| 8/10/2010 10:56:32 AM |